Dentin–Pulp Complex Response in Molars of Rats after Occlusal and Cervical Restorations with Conventional Glass Ionomer Cement and Nano-Hydroxyapatite Silica Glass Ionomer Cement

The purpose of this in vivo study was to evaluate and compare the dentin–pulp complex response following occlusal cervical restorations rat molars restored with nano-hydroxyapatite silica glass ionomer cement (nano-HA-SiO2-GIC) conventional (c-GIC). In total, 64 maxillary first 32 male Wistar rats were using Fuji IX (c-GIC) nano-HA-SiO2-GIC a split-mouth design. Half them reserved for type restoration while other half restorations. After one week month, euthanized stained hematoxylin eosin, Masson’s trichrome, Brown Brenn techniques histological examination. Parameters such as disorganization pulp tissue, inflammatory cell infiltration, detection bacteria, tertiary dentin deposition measured each group. One after sacrifice, odontoblastic layer disrupted, moderate inflammation area close cut observed both types Nano-HA-SiO2-GIC showed significantly superior properties when assessed based on formation compared c-GIC. month there no evidence disruptions odontoblast layer, which exhibited normal palisade appearance groups. terms inflammation, tissue recovered almost all cases except c-GIC, but few group still displayed mild-to-moderate reactions, especially type. Both c-GIC favorable responses biocompatibility. exerted more encouraged better